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Association of British Clinical Diabetologists (ABCD) and Diabetes UK joint position statement and recommendations on the use of sodium-glucose cotransporter inhibitors with insulin for treatment of type 1 diabetes (Updated October 2020)

HIF- is hydroxylated by prolyl hydroxylases (PHDs) that are recognized by the von HippelLindau protein (pVHL), causing HIF- to be ubiquitinated and degraded by the proteasome

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The accumulation of -syn into prefibrillar forms, and then its assembly into higher molecular weight aggregates, induces cellular toxicity and maybe the greatest contributor to pathogenesis in PD (Bengoa-Vergniory et al., Figure 1 Synaptic Vesicle Impairment -syn is typically localized to the presynaptic terminal where it associates with synaptic vesicles and influences membrane curvature (Maroteaux et al., 1988